The Hitchhiker's Guide to the Galaxy is a science fiction comedy series (originally on the radio) about a special book that is a guide to the galaxy. When Dr. Rodney McKay mentioned the amount of addresses in the Atlantis database that did not have accompanying details, Lt. Colonel John Sheppard answered with "42". (SGA: "Doppelganger")

Rodney McKay also had 42 as part of his password. (SGA: "Quarantine")

Dr. Daniel Jackson (as part of a interface chair program on Destiny) told Dr. Nicholas Rush that the number 46 can't be the meaning of life and everything because that's 42. He goes on to tell Rush that it's from The Hitchhiker's Guide to the Galaxy. (SGU: "Human")

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