After her daughter-in-law left her son during his childhood, she raised her grandson. She considered Vernon's mother to be "a real floozy."
She was supposed to take multiple pills on a daily basis but never took any of them as she believed that "those doctors will be the death of us all."
She believed her grandson's claims that the government experimented on him during his service in the Gulf War.
When Vernon was exposed to the Dimension observer in 2002, Major Samantha Carter and Jonas Quinn came to see if Mrs. Sharpe knew were he was. She commented that Carter and Jonas made a nice couple. (SG1: "Sight Unseen")