The Replicator disruptor cannon was a larger, ship-mounted variant of the original Replicator disruptor.
The weapon was designed by Thor using the knowledge of the original replicator disruptor developed by Jack O'Neill while he possessed the Ancient knowledge. The weapon was constructed on Thor's ship, the Daniel Jackson. It took 10-30 minutes for the weapon to fully charge before it's first use and the resulting disruptor wave could encompass an entire city and its surroundings. This amount of time seemed to be greatly lessened as Thor was later able to fire the cannon twice in just a few minutes, but it may merely need to be charged and then can be fired more than once.
The weapon was used to destroy most of the Replicators that invaded Orilla, except for the ship that got away before the weapon was fully charged. The weapon was used again when the Replicators invaded the Milky Way to destroy the Replicators Ha'tak they controlled, but the weapon was rendered useless after the Replicators led by Sam Carter's Replicator twin, Replicator Carter developed an immunity to the weapon which she ultimately spread to the rest of her kind. (SG1: "New Order, Part 2", "Reckoning, Part 1")