With Queen Death's failed attempted at another invasion of Atlantis, she is mustering her forces to destroy the city, once and for all. She sends a single hive with an escort cruiser to scout and get a sense of the defense that will be mounted.
The hive and it's escort jump out of hyperspace, and start scanning for Atlantis. They close on the planet to get a better look, but they are intercepted by the two battlecruisers. At this point the Tau'ri learn that the hive is using an energy shield, something they have never previously encountered on a Wraith ship. A long fight ensues, with the Hammond keeping the hive busy while the Daedalus takes out the cruiser. Although the cruiser is disabled the Daedalus takes damage to their engines, redering them unmovable. The Hammond continues to fight, keeping the inert cruiser between it and the hive. As Colonel Carter prepares to crash the ship into the hive in a last desperate measure, after beaming off her crew, but then the beams go offline and she prepares for the kamikaze run. In the last minute the Daedalus, now fixed, attacks the hive and their combines firepower is enough to destroy the hive. (SGA, "The Lost")
This is one of the first times that human ships have been able to take down a hive without nuclear warheads, Ancient weapons or such.